代谢功能障碍相关脂肪性肝病前沿研究 MDPI Livers。期刊名：Livers

　　 期刊主页： https://www.mdpi.com/journal/livers

　　 本期编辑荐读为您精选Livers期刊中16篇近年佳作，聚焦代谢功能障碍相关脂肪性肝病（MAFLD）这一热点领域。内容涵盖发病机制、临床诊疗、干预策略、基础实验及转化医学等多个方向，汇总了当下学界关注度最高的研究成果与前沿探索。希望这些精选文献，能为广大肝病学领域的专家、学者及临床工作者提供参考与思路，助力相关研究与临床实践开展。

　　 1. Low Hepatic CEACAM1 Tethers Metabolic Dysfunction Steatohepatitis to Atherosclerosis

　　 肝脏 CEACAM1 表达下调介导代谢相关脂肪性肝炎与动脉粥样硬化的关联

　　 http://www.mdpi.com/2673-4389/5/3/34

　　 El Khoury, S.; Al Harake, S.N.; Youssef, T.; Risk, C.E.; Helou, N.G.; Doumet, N.M.; Aramouni, K.; Azar, S.; Najjar, S.M.; Ghadieh, H.E. Low Hepatic CEACAM1 Tethers Metabolic Dysfunction Steatohepatitis to Atherosclerosis. Livers 2025, 5, 34. https://doi.org/10.3390/livers5030034

　　 2. Statin Use in Metabolic Dysfunction-Associated Steatotic Liver Disease and Effects on Vibration-Controlled Transient Elastography-Derived Scores—A Population-Based Inverse Probability Treatment Weighting Analysis

　　 他汀类药物在代谢功能障碍相关脂肪肝疾病中的应用及其对振动控制瞬时弹性成像评分的影响——基于人群的逆概率加权分析

　　 http://www.mdpi.com/2673-4389/4/4/46

　　 Polpichai, N.; Saowapa, S.; Jaroenlapnopparat, A.; Sierra, L.; Danpanichkul, P.; Fangsaard, P.; Wattanachayakul, P.; Kaewdech, A. Statin Use in Metabolic Dysfunction-Associated Steatotic Liver Disease and Effects on Vibration-Controlled Transient Elastography-Derived Scores—A Population-Based Inverse Probability Treatment Weighting Analysis. Livers 2024, 4, 677-687. https://doi.org/10.3390/livers4040046

　　 3. Gender Differences in Healthy Eating Index as Informed by the Awareness of Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease

　　 根据对代谢功能障碍相关脂肪肝疾病诊断的认知程度，探讨健康饮食指数的性别差异

　　 http://www.mdpi.com/2673-4389/5/4/61

　　 Lin, W.-T.; Novack, M.; Liangpunsakul, S.; Huang, C.-K.; Lin, H.-Y.; Chen, P.-H.; Tseng, T.-S.; Ting, P.-S. Gender Differences in Healthy Eating Index as Informed by the Awareness of Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease. Livers 2025, 5, 61. https://doi.org/10.3390/livers5040061

　　 4. Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications

　　 肠道菌群与代谢功能障碍相关脂肪肝病（MASLD）：新兴的致病机制和治疗意义

　　 http://www.mdpi.com/2673-4389/5/1/11

　　 Abdelhameed, F.; Mustafa, A.; Kite, C.; Lagojda, L.; Dallaway, A.; Than, N.N.; Kassi, E.; Kyrou, I.; Randeva, H.S. Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications. Livers 2025, 5, 11. https://doi.org/10.3390/livers5010011

　　 5. Exploring the Role of Probiotics, Prebiotics, and Synbiotics in the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease—A Scoping Review

　　 探索益生菌、益生元和合生元在代谢功能障碍相关脂肪肝疾病治疗中的作用——一项范围综述

　　 http://www.mdpi.com/2673-4389/5/3/31

　　 Ntikoudi, A.; Papachristou, A.; Spirou, A.; Evangelou, E.; Tsartsalis, A.; Vlachou, E.; Mastorakos, G. Exploring the Role of Probiotics, Prebiotics, and Synbiotics in the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease—A Scoping Review. Livers 2025, 5, 31. https://doi.org/10.3390/livers5030031

　　 6. Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex

　　 代谢综合征、肝脂肪变性和睾酮：性别问题

　　 http://www.mdpi.com/2673-4389/4/4/38

　　 Gangitano, E.; Scannapieco, F.; Lubrano, C.; Gnessi, L. Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex. Livers 2024, 4, 534-549. https://doi.org/10.3390/livers4040038

　　 7. Sarcopenia and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review

　　 肌少症和代谢功能障碍相关脂肪肝：叙述性综述

　　 http://www.mdpi.com/2673-4389/4/4/35

　　 Abenavoli, L.; Statsenko, M.; Scarlata, G.G.M.; Morano, D.; Myazin, R.; Emelyanov, D. Sarcopenia and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review. Livers 2024, 4, 495-506. https://doi.org/10.3390/livers4040035

　　 8. Metabolic Syndrome and Methotrexate-Associated Liver Injury: Insights from Elastography and Liver Biopsy Study

　　 代谢综合征与甲氨蝶呤相关肝损伤：来自弹性成像和肝活检研究的启示

　　 http://www.mdpi.com/2673-4389/5/4/67

　　 Fennell, K.; Mahmoud, M.; Qureshi, K. Metabolic Syndrome and Methotrexate-Associated Liver Injury: Insights from Elastography and Liver Biopsy Study. Livers 2025, 5, 67. https://doi.org/10.3390/livers5040067

　　 9. A Metabolomics-Based Approach for Diagnosing NAFLD and Identifying Its Pre-Condition Along the Potential Disease Spectrum

　　 基于代谢组学的非酒精性脂肪性肝病诊断及其潜在疾病谱中前驱状态的识别方法

　　 http://www.mdpi.com/2673-4389/5/1/12

　　 Nojima, M.; Kimura, T.; Aoki, Y.; Fujimoto, H.; Hayashi, K.; Ohtake, J.; Kimura-Asami, M.; Suzuki, K.; Urayama, K.; Matsuura, M.; et al. A Metabolomics-Based Approach for Diagnosing NAFLD and Identifying Its Pre-Condition Along the Potential Disease Spectrum. Livers 2025, 5, 12. https://doi.org/10.3390/livers5010012

　　 10. Unveiling the Multifaceted Role of CIDEB: From Apoptosis to Lipid Metabolism and Liver Health

　　 揭示CIDEB的多方面作用：从细胞凋亡到脂质代谢和肝脏健康

　　 http://www.mdpi.com/2673-4389/4/3/30

　　 Wutsdorff, L.; Mougnekabol, J.; Tang, P.; Reutzel-Selke, A.; Sauer, I.M.; Haep, N. Unveiling the Multifaceted Role of CIDEB: From Apoptosis to Lipid Metabolism and Liver Health. Livers 2024, 4, 406-419. https://doi.org/10.3390/livers4030030

　　 11. Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

　　 一例由罕见遗传性疾病——家族性部分脂肪营养不良引起的进行性代谢功能障碍相关脂肪肝病（MASLD）病例报告及文献综述

　　 http://www.mdpi.com/2673-4389/4/4/47

　　 Vorona, E.; Sorkina, E.; Trebicka, J. Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature. Livers 2024, 4, 688-695. https://doi.org/10.3390/livers4040047

　　 12. Linking Psychological Stress to Epigenetic Regulation via the Gut–Liver–Brain Axis in Irritable Bowel Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease

　　 心理压力通过肠-肝-脑轴与肠易激综合征和代谢功能障碍相关脂肪肝疾病的表观遗传调控联系起来

　　 http://www.mdpi.com/2673-4389/5/3/43

　　 Crocetta, A.; Giannelou, M.-A.; Benfante, A.; Castelli, L.; Koumbi, L. Linking Psychological Stress to Epigenetic Regulation via the Gut–Liver–Brain Axis in Irritable Bowel Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease. Livers 2025, 5, 43. https://doi.org/10.3390/livers5030043

　　 13. Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics

　　 理解代谢功能障碍相关脂肪肝疾病中巨噬细胞的复杂性：从 M1/M2 范式过渡到空间动力学

　　 http://www.mdpi.com/2673-4389/4/3/33

　　 Ahamed, F.; Eppler, N.; Jones, E.; Zhang, Y. Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics. Livers 2024, 4, 455-478. https://doi.org/10.3390/livers4030033

　　 14. Applicability of Statins in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

　　 他汀类药物在代谢功能障碍相关脂肪肝病（MASLD）中的应用

　　 http://www.mdpi.com/2673-4389/5/1/4

　　 Prasoppokakorn, T. Applicability of Statins in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Livers 2025, 5, 4. https://doi.org/10.3390/livers5010004

　　 15. Exploring the Classic and Novel Pathogenetic Insights of Plastic Exposure in the Genesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

　　 探索塑料暴露在代谢功能障碍相关脂肪肝病（MASLD）的发生和发展中的经典和新型致病机制见解

　　 http://www.mdpi.com/2673-4389/5/2/21

　　 Romeo, M.; Dallio, M.; Di Nardo, F.; Martinelli, G.; Basile, C.; Silvestrin, A.; Senese, G.; Coppola, A.; Napolitano, C.; Amoresano, A.; et al. Exploring the Classic and Novel Pathogenetic Insights of Plastic Exposure in the Genesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Livers 2025, 5, 21. https://doi.org/10.3390/livers5020021

　　 16. Multifaceted Human Antigen R (HuR): A Key Player in Liver Metabolism and MASLD

　　 多功能人类抗原R (HuR)：肝脏代谢和MASLD的关键参与者

　　 http://www.mdpi.com/2673-4389/5/3/33

　　 Eppler, N.; Jones, E.; Ahamed, F.; Zhang, Y. Multifaceted Human Antigen R (HuR): A Key Player in Liver Metabolism and MASLD. Livers 2025, 5, 33. https://doi.org/10.3390/livers5030033

　　 关于 Livers

　　 Livers期刊主题涵盖肝炎 所有形式；酒精性肝病；非酒精性脂肪性肝病和非酒精性脂性肝炎；肝硬化；胆道疾病；药物性肝损伤；遗传性和代谢性肝病及其并发症；癌症与药物代谢；肝细胞癌；肝纤维化；肝病免疫学；肝病学营养；肝病病理学；肝病的诊断和治疗，为肝病学多学科领域的基础、转化和高级临床研究提供平台。目前已被 ESCI（Web of Science）、Scopus 等国际权威数据库收录。

　　 主编： Prof. Dr. Hartmut W. Jaeschke

　　 University of Kansas Medical Center, USA

　　 副主编：Prof. Dr. Ralf Weiskirchen

　　 RWTH University Hospital Aachen, Germany

　　 2025 Impact Factor 2.2 2025 CiteScore 4.1 Time to First Decision 28 Time to Publication 10.9
来源：Livers